Pilot fatigue is a critical issue in aviation safety, with the potential to impair cognitive function, decision-making, and reaction times. As air travel continues to grow, the demands on pilots have increased, making fatigue management a top priority for airlines and regulatory authorities. Human factors—a multidisciplinary field that examines the interaction between humans and their environment—plays a vital role in understanding and mitigating pilot fatigue. By applying human factors principles, the aviation industry can develop strategies to reduce fatigue, enhance safety, and improve overall performance. This article explores the role of human factors in addressing pilot fatigue and the measures being implemented to combat this challenge. A high-altitude commercial aircraft cockpit scene depicting a fatigued pilot, emphasizing the role of human factors in managing pilot fatigue. The image symbolizes the aviation industry's efforts to enhance safety through fatigue risk managem...